Treatment of Yunnan Baiyao plus Kangfuxin Solution Reduces Inflammatory Response and Prevents Patients with Nasopharyngeal Carcinoma against Radiation-Induced Oral Mucositis

Oral mucositis refers to secondary mucosal damage, which usually occurs during cancer treatment. Generally, patients with head and neck cancers receiving radiotherapy will develop mucositis. begins inflammation is characterized by erythema confluent ulcers. The purpose of the study explore therapeutic effects Yunnan Baiyao combined Kangfuxin solution on radiation-induced oral influence production inflammatory factors in nasopharyngeal carcinoma (NPC) after radiotherapy. Clinical variables 90 NPC were retrospectively analyzed. All underwent treatment (normal saline inhalation dexamethasone, gentamicin, vitamin B12) 1st radiotherapy, among 45 received additional plus assigned as group. We found that remarkably attenuated pain dry mouth reduced degree hyperaemia, edema, ulceration undergoing ( P < 0.05 ). It was also notably inhibited release cancer-related markers, evidenced lower serum levels C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), matrix metalloproteinase-9 (MMP-9), hypoxia-inducible factor-1 α (HIF-1α), vascular endothelial growth factor (VEGF) detected group than control id="M2"> Additionally, numbers CD+3 CD+4 subpopulations T lymphocytes ratio CD+4/CD+8 significantly higher those id="M3"> ), number CD+8 id="M4"> In conclusion, these results indicated reduces response prevents against